Digexin^® is a blend of Withania somnifera (Ashwagandha) root and Hibiscus esculentus (Okra) fruit. Digexin^® offers unique digestive support addressing the symptoms of digestive health issues from the digestive system to the brain. Therefore, Digexin^® could be useful in working on the mind-gut connection.

A randomised, double-blind, placebo-controlled study aimed to establish a proof-of concept evaluating the efficacy and tolerability of digexin^® in relieving constipation and improving quality of life in adults. At the end of the 2-week study, digexin^® subjects showed:

• Reduction in diarrhoea, constipation, indigestion, reflux discomfort
• Improved complete spontaneous bowel movement and bowel performance
• Reduction in stress level
• Improvement in physical function and energy
• Improved sleep quality (awakening from sleep, behaviour following wakefulness, getting to sleep)
• Significant increases in serum serotonin, gastrin, and interleukin-10
• Decrease in interleukin-6 and cortisol levels
• Reduced physical discomfort, psychosocial discomfort, dissatisfaction, and worries and concerns

A randomised, double-blind, placebo-controlled study was to re-evaluate the efficacy and tolerability of digexin^® in alleviating gastrointestinal distress and associated gastrointestinal factors in a larger number of subjects with functional constipation supplemented over an extended period.

This study evaluated gastrointestinal transit time, assessed depression and anxiety levels, and measured serum inflammatory modulators and neuroendocrine factors that modulate gastrointestinal functions to investigate further the effect on psychological and neuroendocrinological factors integral to gastrointestinal dysfunction aetiology and progression.

At the end of the 2-month study, people in the digexin^® group showed:

• Reduction in abdominal pain, constipation, diarrhoea, indigestion, and reflux
• Reduced gastrointestinal transit time
• Improved complete spontaneous bowel movement and bowel performance
• Improved intestinal integrity (reduced serum zonulin)
• Improved sleep quality (awakening from sleep, behaviour following wakefulness, getting to sleep)
• Improved inflammatory modulation (reduced serum IL-6 and increased IL-10)
• Increased gastrin and serotonin serum levels
• Decreased serum cortisol
• Reduced depression and anxiety scores
• Reduced physical discomfort, psychosocial discomfort, dissatisfaction, and worries and concerns

References:

Punukollu et al. A blend of Withania somnifera (L.) Dunal root and Abelmoschus esculentus (L.) Moench fruit extracts relieves constipation and improves bowel function: A proof-of-concept clinical investigation. J Ethnopharmacology. 2024; 318: 116997
Singh et al. A Novel Herbal Composition Alleviates Functional Constipation, Reduces Gastrointestinal Transit Time, and Improves Bowel Function in Adults: A Double-Blind, Randomized Clinical Study. J Am Nutr Assoc. 2024 Aug;43(6):553-566.

For information purposes only. Not a substitute for medical advice. If symptoms persist, talk to a health professional.