logo

 

WHAT IS SIBELIUS SAGE?

Sibelius sage™ is a unique and specific extract of sage species Salvia officianalis.


A Brief History of Sage


Salvia officinalis (also known as garden sage, common sage, or culinary sage) is a perennial, evergreen dwarf shrub.  The plant has  greyish leaves and blue to purplish flowers that bloom in summer. A member of the mint family, it is native to the Mediterranean region, though it is currently grown throughout the world. It has a long history of medicinal and culinary use, and in many homes it is grown as an ornamental garden plant.


The use of Salvia officinalis can be traced back through the centuries.  The genus name Salvia derives from the Latin salvere, meaning “to save,” perhaps referring the
healing properties of plants.  Ancient Greeks, Egyptians and Romans believed  the planto improve memory function, heal minor skin wounds, treat coughes and even help with fertility.

In later years, early English herbalists from the 16th and 17th Century, including John Gerard and Nicholas Culpeper,believed that it was good for the head, brain and memory
 From John Gerard's Herball (1597) on sage "is singularly good for the head and brain, it quickeneth the senses and memory, strengtheneth the sinews, restoreth health to those that have the palsy, and taketh away shakey trembling of the members.”
In India, sage was traditionally used to treat upset stomachs, intestinal gas and infections of the mouth, nose and throat.  Sage oil has also been employed as a fragrance in soaps and perfumes.
A modern story: Sibelius Sage™
Today, the unique and specific Sibelius sage™ extract is derived from plants grown in Hampshire in the UK.  The herbal extract has a unique profile when analysed by NMR spectroscopy and pattern recognition.   Different varieties of Salvia officinalis grown under the same conditions, and even the same variety of Salvia officinalis grown at the same location but harvested at a different time do not present the same under analysis.
Sibelius Sage™ is being studied and developed using the latest cutting edge techniques.
 Sibelius has developed this product using its patented ChronoscreenTM technology, which measures the changes to chronological life span in C.elegans organisms as a result of treatment with ingredients or complex products. The C.elegans organism is widely used as a model for researching conditions associated with cellular ageing making it ideal for testing biological activity in herbal extracts and other natural products.

A human clinical trial investigating the effect of Sibelius sage™ on cognition was conducted with a cohort of healthy seniors. Testing of the cohort showed significant improvements in memory performance of recognition and recall over periods of between one and six hours, in response to a single dose of 333mg input.

 

FAQs


Has there been trials on people?
Yes there has, with great results.  For more information, see our Studies page.


What is Sibelius Sage™
Sibelius sage™ is a specifically grown and harvested extract of sage (Salvia officianalis) that has been tested and clinically trialed for its effects on cognitive processes.  For more information, see our page What is Sibelius Sage™?


Where and how is it grown?
Sibelius sage™ is grown just outside Hampshire in the UK on our farm which is dedicated just to the sage to prevent risk of cross contamination.   The plants are managed under Good Agricultural Practic standards and is harvested between November and March each year.


What dose should I take?
Our clinical trial showed that the 333mg input dose (approximately 2.5 g herbal equivalent) of the Sibelius sage™ has the best outcomes.


What is Chronoscreen™ testing?
ChronoscreenTM is a functional assay of biological activity. It is a phenotypic screen giving a whole organism, whole lifespan readout of an ingredient activity on pathways of cellular aging. Any ingredient can be tested using this model to see the effect on aspects of cellular ageing.


Is Sibelius sage™ GRAS?
GRAS or generally regarded as safe is an international standard for food and herbal ingredients governed by the FDA.  It means they consider the material to be safe for human consumption.   Sibelius sage is GRAS.


How does Sibelius sage™ work?
Sage (Salvia officinalis ) has a long history of traditional use in Western Herbal medicine, including for cognitive support.

The mechanism of action has not been fully uncovered at this time, and this is possibly because it affects a number of different pathways that are involved in cognitive function.  However, at this time there are interesting actions that have been uncovered that may help explain the effect in part.

Neurotransmitters are broken down in the body by enzymes. Sage extracts have been shown to inhibit the action of acetylcholinesterase; the enzyme that breaks down the neurotransmitter acetylcholine.  Acetylcholine is found in the brain in areas associated with attention, memory and motivation.

In addition, sage has been shown to possess antioxidant, anti-inflammatory and estrogenic properties. Hormonal imbalance, inflammation and oxidative stress may all contribute to decreased cognitive function.

More info at sibeliussage.com.au